Saturday, March 31, 2012

citric acid and sodium citrate


Generic Name: citric acid and sodium citrate (SIT rik AS id and SOE dee um SIT rayt)

Brand Names: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit


What is citric acid and sodium citrate?

Citric acid and sodium citrate are both alkalinizing agents that make the urine less acidic.


The combination of citric acid and sodium citrate is used to prevent gout or kidney stones, or metabolic acidosis in people with kidney problems.


Citric acid and sodium citrate may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about citric acid and sodium citrate?


You should not use this medication if you have kidney failure, severe heart damage (such as from a prior heart attack), Addison's disease (an adrenal gland disorder), high levels of potassium in your blood (hyperkalemia), or if you are severely dehydrated or have heat cramps.

Before you take citric acid and sodium citrate, tell your doctor about all your medical conditions, especially kidney disease, heart disease, high blood pressure, a history of heart attack, urinary problems, swelling (edema), or chronic diarrhea (such as ulcerative colitis, Crohn's disease).


Also tell your doctor about all other medications you use, including over-the-counter medications and household remedies.


Citric acid and sodium citrate should be taken after meals to help prevent stomach or intestinal side effects.


The liquid medicine should be mixed with water or juice. Drink plenty of liquids while you are taking citric acid and sodium citrate. Your treatment may include a special diet. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Avoid using antacids without your doctor's advice, including household baking soda (sodium bicarbonate). Antacids that contain aluminum or sodium can interact with citric acid and sodium citrate, causing a serious electrolyte imbalance or aluminum toxicity.


Avoid eating foods that are high in salt, or using extra table salt on your meals.


To be sure citric acid and sodium citrate is helping your condition, your blood and urine may need to be tested often. Follow your doctor's instructions carefully and do not miss any scheduled appointments.


Serious side effects of citric acid and sodium citrate include muscle twitching or cramps, swelling or weight gain, weakness, mood changes, rapid and shallow breathing, fast heart rate, restless feeling, black or bloody stools, severe diarrhea, or seizure (convulsions).


What should I discuss with my healthcare provider before taking citric acid and sodium citrate?


You should not use this medication if you are allergic to it, or if you have:

  • kidney failure;




  • severe heart damage (such as from a prior heart attack);




  • Addison's disease (an adrenal gland disorder);




  • high levels of potassium in your blood (hyperkalemia); or




  • if you are severely dehydrated or have heat cramps.



If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take citric acid and sodium citrate, tell your doctor if you have:


  • kidney disease;


  • congestive heart failure, enlarged heart, or history of heart attack;




  • other heart disease or high blood pressure;




  • low levels of calcium in your blood (hypocalcemia);




  • a urinary tract infection;




  • toxemia of pregnancy;




  • urination problems (or if you are unable to urinate);




  • swelling of your hands or feet, or in your lungs (pulmonary edema); or




  • chronic diarrhea (such as ulcerative colitis, Crohn's disease).




It is not known whether this medication is harmful to an unborn baby. Before taking citric acid and sodium citrate, Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether citric acid and sodium citrate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take citric acid and sodium citrate?


Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.


Citric acid and sodium citrate should be taken after meals to help prevent stomach or intestinal side effects. You may also need to take the medicine at bedtime. Follow your doctor's instructions.


Shake the oral solution (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. The liquid medicine should be mixed with at lease 4 ounces of water or juice. Drink this mixture slowly and then add a little more water to the same glass, swirl gently and drink right away. You may chill the mixed medicine to make it taste better, but do not allow it to freeze.

Drink plenty of liquids while you are taking citric acid and sodium citrate.


Your treatment may include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

To be sure citric acid and sodium citrate is helping your condition, your blood and urine may need to be tested often. Follow your doctor's instructions carefully and do not miss any scheduled appointments.


Store citric acid and sodium citrate at room temperature away from moisture, heat, or freezing. Keep the medication in a closed container.

What happens if I miss a dose?


Take the missed dose as soon as you remember. If you are more than 2 hours late in taking your medicine, wait until your next regularly scheduled time to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include muscle spasms or seizure (convulsions).


What should I avoid while taking citric acid and sodium citrate?


Avoid using antacids without your doctor's advice, including household baking soda (sodium bicarbonate). Antacids that contain aluminum or sodium can interact with citric acid and sodium citrate, causing a serious electrolyte imbalance or aluminum toxicity.


Avoid eating foods that are high in salt, or using extra table salt on your meals.


It is very important to follow any diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.


Citric acid and sodium citrate side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, tingling, or numbness in your hands or feet;




  • muscle twitching or pain, leg pain or cramps;




  • unusual weakness, rapid and shallow breathing, fast or slow heart rate, dizziness, confusion, or mood changes;




  • feeling restless, nervous, or irritable;




  • black, bloody, or tarry stools;




  • severe or ongoing diarrhea; or




  • seizure (convulsions).



Less serious side effects may include:



  • nausea, or vomiting, stomach pain;




  • mild or occasional diarrhea; or




  • mild stomach pain.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect citric acid and sodium citrate?


The following drugs can interact with citric acid and sodium citrate. Tell your doctor if you are using any of these:



  • lithium (Eskalith, LithoBid);




  • methenamine (Hiprex, Mandelamine, Urex),




  • quinidine (Quinaglute, Quinidex, Quin-Release);




  • cold or allergy medicine (decongestants), diet pills, ADHD medication;




  • a vitamin, mineral supplement, or medication that contains calcium;




  • salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Tricosal, and others; or




  • an antacid that contains aluminum or sodium, including Alka-Seltzer, Maalox, Mylanta, Di-Gel, Gelusil, Alamag Plus, Rulox Plus, Tempo, and others.



This list is not complete and there may be other drugs that can interact with citric acid and sodium citrate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More citric acid and sodium citrate resources


  • Citric acid and sodium citrate Side Effects (in more detail)
  • Citric acid and sodium citrate Use in Pregnancy & Breastfeeding
  • Citric acid and sodium citrate Drug Interactions
  • Citric acid and sodium citrate Support Group
  • 0 Reviews for Citric acid and sodium citrate - Add your own review/rating


Compare citric acid and sodium citrate with other medications


  • Urinary Alkalinization
  • Urinary Tract Stones


Where can I get more information?


  • Your pharmacist can provide more information about citric acid and sodium citrate.

See also: citric acid and sodium citrate side effects (in more detail)


Thursday, March 29, 2012

Bronchodilators


Bronchodilators are agents that widen the air passages by relaxing the bronchial smooth muscle. Bronchodilators are either short-acting or long-acting beta2-agonists, anticholinergic agents or theophylline. They are used to control symptoms of asthma and chronic obstructive pulmonary diseases.


Short acting bronchodilators are used when needed for quick relief of asthma symptoms and long acting bronchodilators are used regularly to control symptoms of asthma.

See also

  • adrenergic bronchodilators
  • anticholinergic bronchodilators
  • bronchodilator combinations
  • methylxanthines

Drug List:

Tuesday, March 27, 2012

Ciclopirox Topical Suspension




Ciclopirox

Topical Suspension USP, 0.77% w/w

Rx Only


FOR DERMATOLOGIC USE ONLY

NOT FOR OPHTHALMIC USE



Ciclopirox Topical Suspension Description


Ciclopirox Topical Suspension USP, 0.77% is for topical use.


Each gram of Ciclopirox Topical Suspension USP contains 7.70 mg of ciclopirox (as ciclopirox olamine) in a water miscible suspension base consisting of cetyl alcohol, cocamide DEA, lactic acid, mineral oil, myristyl alcohol, octyldodecanol, polysorbate 60, purified water, sorbitan monostearate, stearyl alcohol, and benzyl alcohol (1%) as preservative.


Ciclopirox Topical Suspension USP contains a synthetic, broad-spectrum, antifungal agent ciclopirox (as ciclopirox olamine). The chemical name is 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt.


The CAS Registry Number is 41621-49-2.


The chemical structure is:



Ciclopirox Topical Suspension USP has a pH of 7.



Ciclopirox Topical Suspension - Clinical Pharmacology


Ciclopirox is a broad-spectrum, antifungal agent that inhibits the growth of pathogenic dermatophytes, yeasts, and Malassezia furfur. Ciclopirox exhibits fungicidal activity in vitro against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, and Candida albicans.


Pharmacokinetic studies in men with radiolabeled ciclopirox solution in polyethylene glycol 400 showed an average of 1.3% absorption of the dose when it was applied topically to 750 cm2 on the back followed by occlusion for 6 hours. The biological half-life was 1.7 hours and excretion occurred via the kidney. Two days after application only 0.01% of the dose applied could be found in the urine. Fecal excretion was negligible. Autoradiographic studies with human cadaver skin showed that ciclopirox penetrates into the hair and through the epidermis and hair follicles into the sebaceous glands and dermis, while a portion of the drug remains in the stratum corneum.


In vitro penetration studies in frozen or fresh excised human cadaver and pig skin indicated that the penetration of Ciclopirox Topical Suspension USP is equivalent to that of Ciclopirox Cream USP. Therapeutic equivalence of cream and suspension formulations also was indicated by studies of experimentally induced guinea pig and human trichophytosis.



Indications and Usage for Ciclopirox Topical Suspension


Ciclopirox Topical Suspension USP is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; cutaneous candidiasis (moniliasis) due to Candida albicans; and tinea (pityriasis) versicolor due to Malassezia furfur.



Contraindications


Ciclopirox Topical Suspension USP is contraindicated in individuals who have shown hypersensitivity to any of its components.



Warnings



General


Ciclopirox Topical Suspension USP is not for ophthalmic use.


Keep out of reach of children.



Precautions


If a reaction suggesting sensitivity or chemical irritation should occur with the use of Ciclopirox Topical Suspension USP, treatment should be discontinued and appropriate therapy instituted.



Information for Patients


The patient should be told to:


  1. Use the medication for the full treatment time even though signs/symptoms may have improved and notify the physician if there is no improvement after four weeks.

  2. Inform the physician if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing) indicative of possible sensitization.

  3. Avoid the use of occlusive wrappings or dressings.


Carcinogenesis, Mutagenesis, Impairment of Fertility


A carcinogenicity study in female mice dosed cutaneously twice per week for 50 weeks followed by a 6-month drug-free observation period prior to necropsy revealed no evidence of tumors at the application site. The following in vitro and in vivo genotoxicity tests have been conducted with ciclopirox olamine: studies to evaluate gene mutation in the Ames Salmonella/Mammalian Microsome Assay (negative) and Yeast Saccharomyces Cerevisiae Assay (negative) and studies to evaluate chromosome aberrations in vivo in the Mouse Dominant Lethal Assay and in the Mouse Micronucleus Assay at 500 mg/kg (negative). The following battery of in vitro genotoxicity tests were conducted with ciclopirox: a chromosome aberration assay in V79 Chinese Hamster Cells, with and without metabolic activation (positive); a gene mutation assay in the HGPRT – test with V79 Chinese Hamster Cells (negative); and a primary DNA damage assay (i.e., unscheduled DNA Synthesis Assay in A549 Human Cells (negative)). An in vitro Cell Transformation Assay in BALB/C3T3 Cells was negative for cell transformation. In an in vivo Chinese Hamster Bone Marrow Cytogenetic Assay, ciclopirox was negative for chromosome aberrations at 5000 mg/kg.



Pregnancy Category B


Reproduction studies have been performed in the mouse, rat, rabbit, and monkey, via various routes of administration, at doses 10 times or more the topical human dose and have revealed no significant evidence of impaired fertility or harm to the fetus due to ciclopirox. There are, however, no adequate or well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.



Nursing Mothers


It is not known whether this drug is excreted in human milk. Caution should be exercised when Ciclopirox Topical Suspension USP, 0.77% is administered to a nursing woman.



Pediatric Use


Safety and effectiveness in pediatric patients below the age of 10 years have not been established.



Adverse Reactions


In the controlled clinical trial with 89 patients using Ciclopirox Topical Suspension and 89 patients using the vehicle, the incidence of adverse reactions were low. Those considered possibly related to treatment or occurring in more than one patient were pruritus, which occurred in two patients using Ciclopirox Topical Suspension and one patient using the suspension vehicle, and burning, which occurred in one patient using Ciclopirox Topical Suspension.



Ciclopirox Topical Suspension Dosage and Administration


Gently massage Ciclopirox Topical Suspension USP, 0.77% into the affected and surrounding skin areas twice daily, in the morning and evening. Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment. If a patient shows no clinical improvement after four weeks of treatment with Ciclopirox Topical Suspension USP, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.



How is Ciclopirox Topical Suspension Supplied


Ciclopirox Topical Suspension USP, 0.77% is supplied in 30 mL (NDC 51672-1323-3) and 60 mL (NDC 51672-1323-4) bottles.


Bottle space provided to allow for vigorous shaking before each use.



Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].



Mfd. by: Taro Pharmaceuticals Inc.

Brampton, Ontario, Canada L6T 1C1

Issued: November 2004


PK- 4740-0


0205-0


126



PRINCIPAL DISPLAY PANEL - 60 mL Bottle Carton


60 mL


NDC 51672-1323-4


Ciclopirox


Topical Suspension


USP, 0.77% (w/w)


FOR DERMATOLOGIC

USE ONLY.


NOT FOR

OPHTHALMIC USE.


Bottle space provided

to allow for vigorous

shaking before each use.


Keep this and all

medications out of the

reach of children.


Rx only


TARO










CICLOPIROX 
ciclopirox  suspension










Product Information
Product TypeHUMAN PRESCRIPTION DRUGNDC Product Code (Source)51672-1323
Route of AdministrationTOPICALDEA Schedule    








Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Ciclopirox Olamine (Ciclopirox)Ciclopirox7.7 mg  in 1 mL


























Inactive Ingredients
Ingredient NameStrength
benzyl alcohol 
cetyl alcohol 
coco diethanolamide 
lactic acid 
mineral oil 
myristyl alcohol 
octyldodecanol 
polysorbate 60 
water 
sorbitan monostearate 
stearyl alcohol 


















Product Characteristics
ColorWHITEScore    
ShapeSize
FlavorImprint Code
Contains      






















Packaging
#NDCPackage DescriptionMultilevel Packaging
151672-1323-31 BOTTLE In 1 CARTONcontains a BOTTLE
130 mL In 1 BOTTLEThis package is contained within the CARTON (51672-1323-3)
251672-1323-41 BOTTLE In 1 CARTONcontains a BOTTLE
260 mL In 1 BOTTLEThis package is contained within the CARTON (51672-1323-4)










Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
ANDAANDA07709208/10/2005


Labeler - Taro Pharmaceuticals U.S.A., Inc. (145186370)









Establishment
NameAddressID/FEIOperations
Taro Pharmaceuticals Inc.206263295MANUFACTURE
Revised: 01/2012Taro Pharmaceuticals U.S.A., Inc.

Antithyroid agents


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Antithyroid agents prevent or suppress the biosynthesis of thyroid hormones. Antithyroid agents are used to treat hyperthyroidism by inhibiting the excessive production of thyroid hormones or by decreasing thyroid hormone activity.

See also

Medical conditions associated with antithyroid agents:

  • Alcoholic Liver Damage
  • Cough
  • Cutaneous Sporotrichosis
  • Diagnosis and Investigation
  • Hyperthyroidism
  • Radiation Emergency
  • Thyroid Cancer
  • Thyroid Storm

Drug List:

Momexin Cream


Pronunciation: moe-MET-a-sone/a-MOE-nee-um LAK-tate
Generic Name: Mometasone Cream and Ammonium Lactate Mousse
Brand Name: Momexin


Momexin Cream is used for:

Treating itching, redness, and swelling caused by certain skin conditions.


Momexin Cream is a kit that contains a topical corticosteroid and a humectant. The corticosteroid reduces skin inflammation (redness, swelling, itching, and irritation). The humectant moisturizes and softens the skin.


Do NOT use Momexin Cream if:


  • you are allergic to any ingredient in Momexin Cream or to other corticosteroid medicines (eg, prednisone)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Momexin Cream:


Some medical conditions may interact with Momexin Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have acne-like lesions; measles; inflammation around your mouth; positive tuberculin skin test; tuberculosis; varicella (chickenpox); have recently had a vaccination; have a skin infection or thinning of the skin (atrophy)

  • if you are taking an oral corticosteroid (eg, prednisone)

Some MEDICINES MAY INTERACT with Momexin Cream. Because little, if any, of Momexin Cream is absorbed into the blood, the risk of it interacting with another medicine is low.


Ask your health care provider if Momexin Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Momexin Cream:


Use Momexin Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • To use the mometasone cream: Apply a small amount of medicine to the affected area as directed by your doctor. Gently rub the medicine in until it is evenly distributed. Wash your hands after applying the medicine, unless your hands are part of the treated area.

  • To apply the ammonium lactate mousse: Hold the mousse can upright and push the nozzle to dispense. Do not turn the can upside down. Gently massage a thin layer of the mousse into the affected area as directed by your doctor.

  • Do not use Momexin Cream on your face, groin, or underarms unless your doctor tells you otherwise.

  • Do not apply Momexin Cream in the diaper area unless your doctor tells you otherwise.

  • Do not use Momexin Cream over large areas of the body without first checking with your doctor.

  • Do not bandage or cover the affected area unless directed to do so by your doctor.

  • If you miss a dose of Momexin Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Momexin Cream.



Important safety information:


  • This is for external use only. Do not get it in your eyes, nose, mouth, on your lips, or near your genital area. If you get it in any of these areas, rinse right away with cool water.

  • Do NOT use more than the recommended dose or use for longer than 2 weeks without checking with your doctor.

  • If your symptoms do not get better within 2 weeks or if they get worse, check with your doctor.

  • Talk with your doctor before you use any other medicines or cleansers on your skin.

  • Use Momexin Cream only for the skin problem for which it is intended.

  • Ammonium lactate may cause temporary stinging or burning when applied to cracked or scraped skin (eg, after shaving).

  • Ammonium lactate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Momexin Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Momexin Cream has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid (eg, hydrocortisone) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Tell your doctor or dentist that you use Momexin Cream before you receive any medical or dental care, emergency care, or surgery.

  • Serious side effects may occur if too much of Momexin Cream is absorbed through the skin. This may be more likely to occur if you use Momexin Cream over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Momexin Cream. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.

  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Momexin Cream.

  • Caution is advised when using Momexin Cream in CHILDREN; they may be more sensitive to its effects.

  • Momexin Cream should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Momexin Cream while you are pregnant. It is not known if Momexin Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Momexin Cream, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Momexin Cream:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Mild burning, itching, peeling, redness, or stinging.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning, itching, numbness, peeling, redness, stinging, or tingling not present before you began using Momexin Cream; inflamed hair follicles; inflammation around the mouth; muscle weakness; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; confusion; unusual drowsiness; flushing; rapid breathing); thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Momexin side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Momexin Cream:

Store the cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Momexin Cream out of the reach of children and away from pets.


Store the mousse at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not store at temperatures above 120 degrees F (49 degrees C). Store away from heat and direct sunlight. Do not puncture, break, or burn the canister even if it appears to be empty. Keep Momexin Cream out of the reach of children and away from pets.


General information:


  • If you have any questions about Momexin Cream, please talk with your doctor, pharmacist, or other health care provider.

  • Momexin Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Momexin Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Momexin resources


  • Momexin Side Effects (in more detail)
  • Momexin Use in Pregnancy & Breastfeeding
  • Momexin Drug Interactions
  • Momexin Support Group
  • 0 Reviews · Be the first to review/rate this drug

Miconazole Lotion


Pronunciation: mi-KON-a-zole
Generic Name: Miconazole
Brand Name: Zeasorb-AF


Miconazole Lotion is used for:

Treating athlete's foot, jock itch, or ringworm and relieving the itching, scaling, burning, and discomfort due to those conditions. It may also be used for other conditions as determined by your doctor.


Miconazole Lotion is an antifungal. It works by weakening the fungal cell membrane, which kills the fungus.


Do NOT use Miconazole Lotion if:


  • you are allergic to any ingredient in Miconazole Lotion

Contact your doctor or health care provider right away if any of these apply to you.



Before using Miconazole Lotion:


Some medical conditions may interact with Miconazole Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Miconazole Lotion. Because little, if any, of Miconazole Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.


This may not be a complete list of all interactions that may occur. Ask your health care provider if Miconazole Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Miconazole Lotion:


Use Miconazole Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Shake well before using a dose of Miconazole Lotion.

  • Clean the affected area and dry it thoroughly.

  • Apply a thin layer of medicine over the affected area in the morning and evening unless directed otherwise by your doctor. Rub in gently.

  • Wash hands immediately after using Miconazole Lotion unless your hands are part of the treated area.

  • For athlete's foot, pay special attention to the area between the toes. Wear well-fitting, ventilated shoes, and change your shoes and socks at least once daily.

  • To clear up your infection completely, continue using Miconazole Lotion for the full course of treatment even if you feel better in a few days.

  • Supervise children in the use of this product.

  • If you miss a dose of Miconazole Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Miconazole Lotion.



Important safety information:


  • Miconazole Lotion is for external use only. Avoid contact with the eyes. If you get Miconazole Lotion in your eyes, rinse them immediately with a generous amount of cool water.

  • If Miconazole Lotion is swallowed, contact a doctor or poison control center immediately.

  • Miconazole Lotion is flammable. Do not store or use near fire or other open flame. Do not use while smoking.

  • Do not cover the treated area with a bandage or dressing unless directed otherwise by your doctor.

  • If there is no improvement of athlete's foot or ringworm within 4 weeks or jock itch within 2 weeks, or if your condition persists, contact your health care provider.

  • Miconazole Lotion is not effective on the scalp or nails.

  • Do not use on CHILDREN younger than 2 years of age unless directed by a doctor.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Miconazole Lotion, discuss with your doctor the benefits and risks of using Miconazole Lotion during pregnancy. It is unknown if Miconazole Lotion is excreted in breast milk. If you are or will be breast-feeding while you are using Miconazole Lotion, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Miconazole Lotion:


All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:



Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); irritation.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Miconazole Lotion:

Store Miconazole Lotion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Miconazole Lotion out of the reach of children and away from pets.


General information:


  • If you have any questions about Miconazole Lotion, please talk with your doctor, pharmacist, or other health care provider.

  • Miconazole Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Miconazole Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Miconazole resources


  • Miconazole Use in Pregnancy & Breastfeeding
  • Miconazole Drug Interactions
  • Miconazole Support Group
  • 8 Reviews for Miconazole - Add your own review/rating


Compare Miconazole with other medications


  • Cutaneous Candidiasis
  • Oral Thrush
  • Tinea Corporis
  • Tinea Cruris
  • Tinea Pedis
  • Tinea Versicolor
  • Vaginal Yeast Infection

Monday, March 26, 2012

Abraxane


Generic Name: paclitaxel protein-bound (Intravenous route)


pak-li-TAX-el PROE-teen - bownd


Intravenous route(Powder for Suspension)

Paclitaxel protein-bound particles therapy should not be administered to patients with metastatic breast cancer who have baseline neutrophil counts of less than 1500 cells/mm(3). It is recommended that frequent peripheral blood cell counts be performed on all patients in order to monitor for the occurrence of bone marrow suppression. An albumin form of paclitaxel may substantially affect a drug's functional properties relative to those of drug in solution. Do not substitute for or with other paclitaxel formulations .



Commonly used brand name(s)

In the U.S.


  • Abraxane

Available Dosage Forms:


  • Powder for Suspension

Therapeutic Class: Antineoplastic Agent


Pharmacologic Class: Mitotic Inhibitor


Uses For Abraxane


Paclitaxel protein-bound belongs to the group of medicines called antineoplastics. It is used to treat cancer of the breast after other treatments have failed.


Paclitaxel interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by paclitaxel protein-bound, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur until months or years after the medicine is used.


Before you begin treatment with paclitaxel protein-bound, you and your doctor should talk about the good this medicine will do as well as the risks of using it.


This medicine is available only with your doctor's prescription.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, paclitaxel protein-bound is used in certain patients with the following medical condition:


  • Metastatic breast cancer, used alone for the treatment of breast cancer that has spread.

Before Using Abraxane


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of paclitaxel protein-bound in the pediatric population. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of paclitaxel protein-bound in the elderly.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Ethinyl Estradiol

  • Testosterone

  • Tretinoin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Infection—May decrease your body's ability to fight infection.

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

  • Neutropenia (low white blood cells)—Should not be used in patients with this condition.

  • Sensory neuropathy, grade 3—Condition may cause a change to the treatment schedule or dose.

Proper Use of Abraxane


You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.


Precautions While Using Abraxane


It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.


Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.


Men who receive paclitaxel protein-bound should not father a child.


Paclitaxel can temporarily lower the number of white blood cells in your blood, which will increase the chance of getting an infection. It can also lower the number of platelets in your blood, which are necessary for proper blood clotting. If this occurs, these are the precautions you can take to reduce the risk of infection or bleeding:


  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection, or if you get a fever or chills, cough or hoarseness, lower back or side pain, or have painful or difficult urination.

  • Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in your urine or stools; or pinpoint red spots on your skin.

  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.

  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.

  • Be careful not to cut yourself when you are using sharp objects, such as a safety razor, fingernail clippers, or toenail clippers.

  • Avoid contact sports or other situations where bruising or injury could occur.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.


Stop using this medicine and check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called sensory neuropathy.


Check with your doctor right away if you have bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.


This medicine may cause some people to become drowsy, tired, weak, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are drowsy or not alert.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


Abraxane Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor or nurse immediately if any of the following side effects occur:


More common
  • Black, tarry stools

  • blurred or double vision

  • chest pain

  • chills

  • cough

  • fever

  • loss of taste

  • lower back or side pain

  • painful or difficult urination

  • pale skin

  • shortness of breath

  • sneezing

  • sore mouth or tongue

  • sore throat

  • tightness in the chest

  • troubled breathing with exertion

  • ulcers, sores, or white spots in the mouth

  • unusual bleeding or bruising

  • unusual tiredness or weakness

  • wheezing

  • white patches in the mouth or on the tongue

Less common
  • Abnormal electrocardiogram (ECG)

  • anxiety

  • bleeding

  • bleeding gums

  • blood in the urine or stools

  • burning, tingling, numbness or pain in the hands, arms, feet, or legs

  • confusion

  • difficulty with breathing

  • difficulty with swallowing

  • dizziness or lightheadedness

  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

  • fainting

  • fast, pounding, or irregular heartbeat or pulse

  • low blood pressure or slow pulse

  • pain in the chest, groin, or legs, especially the calves

  • palpitations

  • pinpoint red spots on the skin

  • sensation of pins and needles

  • severe, sudden headache

  • skin itching, rash, or redness

  • slow or irregular heartbeat

  • slurred speech

  • stabbing pain

  • sudden loss of coordination

  • sudden, severe weakness or numbness in the arms or legs

  • sudden, unexplained shortness of breath

  • sweating

  • swelling of the face, throat, or tongue

  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

  • unconsciousness

  • vision changes

Rare
  • Difficulty with speaking

  • headache

  • inability to move the arms, legs, or facial muscles

  • inability to speak

  • numbness or tingling in the face, arms, or legs

  • severe pain in the chest

  • slow speech

  • sudden onset of severe breathing problems

  • trouble speaking, thinking, or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Cracked lips

  • diarrhea

  • difficulty with moving

  • lack or loss of strength

  • loss of hair

  • muscle pain or stiffness

  • nausea

  • pain in the joints

  • swelling

  • vomiting

Less common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site of injection

Rare
  • Nail changes

Observed during clinical trials
  • Disturbed color perception with your eyes

  • halos around lights

  • loss of vision

  • night blindness

  • overbright appearance of lights

  • tunnel vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Abraxane side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Abraxane resources


  • Abraxane Side Effects (in more detail)
  • Abraxane Use in Pregnancy & Breastfeeding
  • Abraxane Drug Interactions
  • Abraxane Support Group
  • 1 Review for Abraxane - Add your own review/rating


  • Abraxane Prescribing Information (FDA)

  • Abraxane MedFacts Consumer Leaflet (Wolters Kluwer)

  • Abraxane Consumer Overview



Compare Abraxane with other medications


  • Breast Cancer
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Friday, March 23, 2012

cetirizine and pseudoephedrine


Generic Name: cetirizine and pseudoephedrine (se TIR i zeen and SOO doe e FED rin)

Brand names: All Day Allergy-D, ZyrTEC-D, Goodsense Cetirizine D-12 Hour


What is cetirizine and pseudoephedrine?

Cetirizine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of cetirizine and pseudoephedrine is used to treat cold or allergy symptoms such as nasal and sinus congestion, sneezing, itching, watery eyes, or runny nose.


Cetirizine and pseudoephedrine may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about cetirizine and pseudoephedrine?


Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You should not use cetirizine and pseudoephedrine if you are allergic to either drug, or if you have narrow-angle glaucoma, severe high blood pressure (hypertension), severe coronary artery disease, if you are unable to urinate, or if you are allergic to hydralazine (Atarax, Vistaril).


Do not use any other over-the-counter cold medication without first asking your doctor or pharmacist. Pseudoephedrine is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of this drug. Read the label of any other medicine you are using to see if it contains pseudoephedrine.


Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine. Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

What should I discuss with my healthcare provider before taking cetirizine and pseudoephedrine?


Do not use cetirizine and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious side effects can occur if you take pseudoephedrine before the MAO inhibitor has cleared from your body. You should not use cetirizine and pseudoephedrine if you are allergic to either drug, or if you have:

  • narrow-angle glaucoma;




  • severe high blood pressure (hypertension);




  • severe coronary artery disease;




  • if you are unable to urinate; or




  • if you are allergic to hydralazine (Atarax, Vistaril).



Ask a doctor or pharmacist about using cetirizine and pseudoephedrine if you have:



  • heart disease, coronary artery disease, high blood pressure, or heart rhythm disorder;




  • diabetes;




  • a thyroid disorder;




  • glaucoma;




  • kidney or liver disease;




  • an enlarged prostate; or




  • problems with urination.




FDA pregnancy category C. It is not known whether cetirizine and pseudoephedrine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Cetirizine and pseudoephedrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from cetirizine and pseudoephedrine.


How should I take cetirizine and pseudoephedrine?


Take this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.


Take one tablet every 12 hours, unless your doctor tells you otherwise. You may take this medication with or without food.


Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. Breaking or opening the pill may cause too much of the medicine to be released at one time. Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store cetirizine and pseudoephedrine at room temperature away from moisture and heat.

See also: Cetirizine and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, headache, nausea, vomiting, sweating, anxiety, drowsiness, increased thirst, fast or pounding heartbeats, trouble sleeping, or problems with urination.


What should I avoid while taking cetirizine and pseudoephedrine?


Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with pseudoephedrine can increase your risk of unpleasant side effects.


Do not use any other over-the-counter cold medication without first asking your doctor or pharmacist. Pseudoephedrine is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of this drug. Read the label of any other medicine you are using to see if it contains pseudoephedrine. Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine.

Cetirizine and pseudoephedrine side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;




  • weakness, tremors (uncontrolled shaking), or sleep problems (insomnia);




  • severe restless feeling, hyperactivity;




  • extreme feeling of fear or confusion;




  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);




  • problems with vision; or




  • urinating less than usual or not at all.



Less serious side effects may include:



  • dizziness, drowsiness;




  • tired feeling;




  • dry mouth;




  • nausea, stomach pain, constipation;




  • problems with concentration; or




  • ringing in your ears.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Cetirizine and pseudoephedrine Dosing Information


Usual Adult Dose for Allergic Rhinitis:

1 tablet (5 mg-120 mg) orally twice daily.

Usual Pediatric Dose for Allergic Rhinitis:

12 years or older:

1 tablet (5 mg-120 mg) orally twice daily.


What other drugs will affect cetirizine and pseudoephedrine?


Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine.

Before taking this medication, tell your doctor if you are also using any of the following drugs:



  • digoxin (digitalis, Lanoxin);




  • blood pressure medication, especially methyldopa (Aldomet), mecamylamine (Inversine), or reserpine; or




  • diet pills, stimulants, or ADHD medications.



This list is not complete and there may be other drugs that can interact with cetirizine and pseudoephedrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More cetirizine and pseudoephedrine resources


  • Cetirizine and pseudoephedrine Side Effects (in more detail)
  • Cetirizine and pseudoephedrine Dosage
  • Cetirizine and pseudoephedrine Use in Pregnancy & Breastfeeding
  • Cetirizine and pseudoephedrine Drug Interactions
  • Cetirizine and pseudoephedrine Support Group
  • 3 Reviews for Cetirizine and pseudoephedrine - Add your own review/rating


Compare cetirizine and pseudoephedrine with other medications


  • Hay Fever


Where can I get more information?


  • Your pharmacist can provide more information about cetirizine and pseudoephedrine.

See also: cetirizine and pseudoephedrine side effects (in more detail)


Wednesday, March 21, 2012

Periostat


Generic Name: doxycycline (DOX i SYE kleen)

Brand Names: Adoxa, Adoxa CK, Adoxa TT, Alodox, Avidoxy, Doryx, Monodox, Oracea, Oraxyl, Periostat, Vibramycin, Vibramycin Calcium, Vibramycin Monohydrate


What is Periostat (doxycycline)?

Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.


Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others.


Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.


Doxycycline may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Periostat (doxycycline)?


Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using doxycycline.


You should not take this medicine if you are allergic to doxycycline or to other tetracycline antibiotics such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Before taking doxycycline, tell your doctor if you have liver disease, kidney disease, asthma, or if you are allergic to sulfites.


Drink plenty of liquids while you are taking doxycycline. Children should not use doxycycline. Doxycycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

What should I discuss with my healthcare provider before taking Periostat (doxycycline)?


You should not take this medicine if you are allergic to doxycycline or to other tetracycline antibiotics such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

To make sure you can safely take doxycycline, tell your doctor if you have any of these other conditions:



  • liver disease;




  • kidney disease; or




  • asthma or sulfite allergy.



If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.


FDA pregnancy category D. Do not use doxycycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.

Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using doxycycline.


Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking doxycycline. Children should not use doxycycline. Doxycycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

How should I take Periostat (doxycycline)?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


Take doxycycline with a full glass of water. Drink plenty of liquids while you are taking doxycycline.

Different brands of doxycycline may have different instructions about taking them with or without food.


Most brands of doxycyline may be taken with food or milk if the medicine upsets your stomach. Take Oracea or Periostat on an empty stomach, at least 1 hour before or 2 hours after a meal.

You may open a Doryx capsule or break up a Doryx tablet and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Drink a full glass (8 ounces) of cool water right away.


Do not crush, break, or open a delayed-release capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time. The enteric coated pill has a special coating to protect your stomach. Breaking the pill will damage this coating.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.


Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Doxycycline will not treat a viral infection such as the common cold or flu.

If you need surgery, tell the surgeon ahead of time that you are using doxycycline. You may need to stop using the medicine for a short time.


Store at room temperature away from moisture and heat. Throw away any unused medicine after the expiration date on the label has passed. Using expired doxycycline can cause damage to your kidneys.

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and diarrhea.


What should I avoid while taking Periostat (doxycycline)?


Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking doxycycline and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.


Avoid exposure to sunlight or tanning beds. Doxycycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.

Periostat (doxycycline) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • severe headache, dizziness, blurred vision;




  • fever, chills, body aches, flu symptoms, swollen glands, rash or itching, joint pain, or general ill feeling;




  • urinating less than usual or not at all;




  • diarrhea that is watery or bloody




  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;




  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;




  • loss of appetite, jaundice (yellowing of the skin or eyes); or




  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.



Less serious side effects may include:



  • mild nausea, mild diarrhea;




  • upset stomach;




  • mild skin rash or itching; or




  • vaginal itching or discharge.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Periostat (doxycycline)?


Tell your doctor about all other medicines you use, especially:



  • cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);




  • isotretinoin (Accutane);




  • tretinoin (Renova, Retin-A, Vesanoid);




  • an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;




  • a product that contains bismuth subsalicylate such as Pepto-Bismol;




  • minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;




  • a blood thinner such as warfarin (Coumadin, Jantoven); or




  • a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).



This list is not complete and other drugs may interact with doxycycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Periostat resources


  • Periostat Side Effects (in more detail)
  • Periostat Use in Pregnancy & Breastfeeding
  • Drug Images
  • Periostat Drug Interactions
  • Periostat Support Group
  • 0 Reviews for Periostat - Add your own review/rating


  • Periostat MedFacts Consumer Leaflet (Wolters Kluwer)

  • Periostat Prescribing Information (FDA)

  • Periostat Advanced Consumer (Micromedex) - Includes Dosage Information

  • Doxycycline Prescribing Information (FDA)

  • Doxycycline Professional Patient Advice (Wolters Kluwer)

  • Doxycycline Monograph (AHFS DI)

  • Doxycycline MedFacts Consumer Leaflet (Wolters Kluwer)

  • Adoxa MedFacts Consumer Leaflet (Wolters Kluwer)

  • Alodox Prescribing Information (FDA)

  • Doryx Prescribing Information (FDA)

  • Doryx Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Doxycycline Calcium Monograph (AHFS DI)

  • Monodox Prescribing Information (FDA)

  • Ocudox Convenience Kit MedFacts Consumer Leaflet (Wolters Kluwer)

  • Oracea Consumer Overview

  • Oracea Prescribing Information (FDA)

  • Vibra-Tabs MedFacts Consumer Leaflet (Wolters Kluwer)

  • Vibramycin Prescribing Information (FDA)



Compare Periostat with other medications


  • Periodontitis


Where can I get more information?


  • Your pharmacist can provide more information about doxycycline.

See also: Periostat side effects (in more detail)


Monday, March 19, 2012

praziquantel


Generic Name: praziquantel (PRAZ i KWON tel)

Brand Names: Biltricide


What is praziquantel?

Praziquantel is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.


Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Caribbean, and parts of Asia.


Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish.


Praziquantel should not be used to treat parasitic infections in the eye.

Praziquantel may also be used for purposes not listed in this medication guide.


What is the most important information I should know about praziquantel?


You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin (Rifadin, Rifater, Rifamate) in the last 4 weeks.

Before taking praziquantel, tell your doctor if you have kidney disease, heart disease, liver disease, or a history of seizures or epilepsy.


Do not give this medication to a child younger than 4 years old. Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Praziquantel should be taken with a meal. Do not crush or chew the praziquantel tablet. Swallow the pill whole. Take this medication with a full glass (8 ounces) of water.

What should I discuss with my healthcare provider before taking praziquantel?


You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin (Rifadin, Rifater, Rifamate) in the last 4 weeks.

To make sure you can safely take praziquantel, tell your doctor if you have any of these other conditions:



  • headaches, confusion;




  • seizures (or a history of seizures or epilepsy);




  • lumps (nodules) under your skin;




  • kidney disease;




  • heart disease; or




  • liver disease.




FDA pregnancy category B. Praziquantel is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Praziquantel can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 4 years old.

How should I take praziquantel?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


Take this medication with a full glass (8 ounces) of water.

Praziquantel is usually taken 3 times in one day. Your doses should be taken 4 to 6 hours apart on that day.


Praziquantel should be taken with a meal.

You may need to break a praziquantel tablet in order to get the correct dose. Follow your doctor's instructions.


Do not crush or chew the praziquantel tablet or portion of a tablet. Swallow the pill whole. Store at room temperature away from moisture and heat.

See also: Praziquantel dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking praziquantel?


Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Grapefruit and grapefruit juice may interact with praziquantel and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.


Praziquantel side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:



  • tired feeling;




  • headache, dizziness;




  • nausea, upset stomach;




  • mild fever; or




  • mild skin rash.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Praziquantel Dosing Information


Usual Adult Dose for Nanophyetus salmincola:

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma japonicum:

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma mekongi:

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma haematobium:

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Adult Dose for Schistosoma mansoni:

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Adult Dose for Fasciolopsis buski (Intestinal Fluke):

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Heterophyes heterophyes (Intestinal Fluke):

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Metagonimus yokogawai (Intestinal Fluke):

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Opisthorchis viverrini (Liver Fluke):

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Clornorchis sinensis (Liver Fluke):

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Paragonimus westermani (Lung Fluke):

25 mg/kg orally every 4 hours for 6 doses (3 doses per day for 2 consecutive days)

Case Report (n=1)
75 mg/kg/day for 3 days

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm):

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm):

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Taenia saginata (beef tapeworm):

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Taenia solium (pork tapeworm):

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm):

25 mg/kg orally one time

Since eradication may be difficult, retreatment is recommended if the infection persists.

Usual Adult Dose for Cysticercus cellulosae (Cysticercosis):

50 mg/kg/day orally in 3 divided doses for 15 days

Concomitant use of corticosteroids during praziquantel therapy for neurocysticercosis may reduce the frequency and severity of an inflammatory response to degeneration of cysts in the central nervous system.

Repeated courses of therapy may be considered in patients with only partial resolution of cysts 3 months after a course or whose condition deteriorates.

Usual Adult Dose for Echinococcus Infection:

Study (n=19)
50 mg/kg once daily, in combination with albendazole, to a maximum of 9 months

Patients unable to tolerate side effects took praziquantel once, twice weekly or once every two weeks.

Usual Pediatric Dose for Nanophyetus salmincola:

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma japonicum:

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma mekongi:

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma haematobium:

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Pediatric Dose for Schistosoma mansoni:

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Pediatric Dose for Fasciolopsis buski (Intestinal Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Heterophyes heterophyes (Intestinal Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Metagonimus yokogawai (Intestinal Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Opisthorchis viverrini (Liver Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Clornorchis sinensis (Liver Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Paragonimus westermani (Lung Fluke):

4 years or older: 25 mg/kg orally every 4 hours for 6 doses (3 doses per day for 2 consecutive days)

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm):

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm):

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Taenia saginata (beef tapeworm):

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Taenia solium (pork tapeworm):

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm):

4 years or older: 25 mg/kg orally one time

Since eradication may be difficult, retreatment is recommended if the infection persists.

Usual Pediatric Dose for Cysticercus cellulosae (Cysticercosis):

4 years or older: 50 mg/kg/day orally in 3 divided doses for 15 days

Concomitant use of corticosteroids during praziquantel therapy for neurocysticercosis may reduce the frequency and severity of an inflammatory response to degeneration of cysts in the central nervous system.


What other drugs will affect praziquantel?


Tell your doctor about all other medications you are using, especially:



  • cimetidine (Tagamet);




  • chloroquine (Aralen);




  • itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);




  • dexamethasone (Decadron, Hexadrol);




  • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);




  • St. John's wort;




  • rifabutin (Mycobutin) or rifapentine (Priftin);




  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);




  • HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);




  • medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or




  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).



This list is not complete and other drugs may interact with praziquantel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More praziquantel resources


  • Praziquantel Side Effects (in more detail)
  • Praziquantel Dosage
  • Praziquantel Use in Pregnancy & Breastfeeding
  • Praziquantel Drug Interactions
  • Praziquantel Support Group
  • 1 Review for Praziquantel - Add your own review/rating


  • praziquantel Advanced Consumer (Micromedex) - Includes Dosage Information

  • Praziquantel Professional Patient Advice (Wolters Kluwer)

  • Praziquantel Monograph (AHFS DI)

  • Praziquantel MedFacts Consumer Leaflet (Wolters Kluwer)

  • Biltricide Prescribing Information (FDA)



Compare praziquantel with other medications


  • Cysticercus cellulosae
  • Dog Tapeworm
  • Echinococcus
  • Fasciolopsis buski, Intestinal Fluke
  • Fish Tapeworm Infection
  • Heterophyes heterophyes, Intestinal Fluke
  • Hymenolepis nana, Dwarf Tapeworm
  • Liver Fluke
  • Metagonimus yokogawai, Intestinal Fluke
  • Naophyetus salmincola
  • Opisthorchis viverrini, Liver Fluke
  • Paragonimus westermani, Lung Fluke
  • Schistosoma haematobium
  • Schistosoma japonicum
  • Schistosoma mansoni
  • Schistosoma mekongi
  • Taenia saginata, beef tapeworm
  • Taenia solium, pork tapeworm


Where can I get more information?


  • Your pharmacist can provide more information about praziquantel.

See also: praziquantel side effects (in more detail)